Sepsis is the body’s extreme response to infection, and recognizing who is most vulnerable can save lives. This article clearly explains high-risk groups—older adults, infants, pregnant and postpartum people, those with chronic conditions (like diabetes, heart, lung, kidney, or liver disease), people with weakened immune systems (from cancer treatment, transplants, HIV, or long-term steroids), and anyone with recent surgery, invasive devices, serious wounds, or infections such as pneumonia or UTIs. It offers practical prevention tips (vaccination, hand and wound care, managing chronic illness) and warning signs to act on—fever or unusually low temperature, fast breathing or heart rate, confusion, extreme pain, or clammy skin—so patients and caregivers can seek urgent help quickly and confidently.