If you were on the M/V Hondius cruise ship linked to an Andes virus (ANDV) outbreak—or had other identified high-risk exposure—CDC guidance includes a 42-day monitoring window after your last potential exposure. This plain-language guide explains what that window means, what to track at home (including daily temperature checks), and what “compatible symptoms” should trigger immediate self-isolation and contact with public health or your clinician. For most people in the general public, CDC says the risk is very low. The most important step is to follow whatever exposure instructions you were given by public health, your clinician, or your local/state health department.