Dr. Donald Frey in Louisville, Kentucky

This article explains what research shows about stress and immunity in clear, practical terms. Short bursts of stress can briefly prime immune defenses, but ongoing stress raises cortisol and inflammatory signals that disrupt immune balance—linking chronic stress to more frequent colds, slower wound healing, and weaker vaccine responses. It highlights who may be most affected (such as caregivers or people with long-term stress), what signs to watch for, and evidence-based ways to protect immune health, including sleep, physical activity, social support, and stress-management techniques. Readers gain reliable guidance on when to seek medical advice and how to build a personalized, sustainable plan.